Deplin is a medication that targets people with depression. The official website states “dietary management of depression with Deplin regulates all 3 monoamine neurotransmitters associated with mood by providing the increased requirements for folate in the brain.”
Is Deplin Right For You?
Deplin is a prescription medication that targets people with varying degrees of depression. This product is manufactured by Panlab, LLC.
Click here to read about a non-prescription potential alternative to Deplin
The official website states that dietary management of depression with this particular formula regulates all 3 monoamine neurotransmitters associated with mood by providing the increased requirements for folate in the brain.
In simple terms, this supplement manages and artificially stimulates neurotransmitter syntheses (aiming at trimonoamine especially). These are the neurotransmitters associated with moods. It does this by increasing the requirement for folate in the brain.
While medications may be the right route for people with severe depression, it should not be the choice for most people. You should always seek medical attention if you are thinking of going down this route.
Ingredients of Deplin
Deplin includes the following ingredients: L-methylfolate [6(S)-5-MTHF](Metafolin), Dibasic Calcium Phosphate Dihydrate, Silicified Microrystalline Cellulose 90,Silicified Microcrystalline Cellulose HD90, Opardy ll Blue85F90748 (Polyvinyl Alcohol, Titanium Dioxide, PEG 3350, Talc and FD&C Blue #2), Magnesium Stearate (Vegetable Source) and Carnauba Wax.
Effectiveness of Deplin
First of all, we would like to point out that all drugs are altering the composition of your brain and creating an unnatural environment. The real goal is that you should get back to a natural state and feel healthy, joyful and alive once again with the right diet and amino acid supplementation. While this might not be possible for people with severe depression, this should be the first means of action for most other people. The brain demands a nourished environment where it can restore health in a natural fashion.
According to the official website, this supplement works by addressing the imbalance in the neurotransmitters in the brain, but they do so by an artificial means. For example, most antidepressants do this by blocking the reabsorption of neurotransmitters, allowing the brain to have greater use of available neurotransmitters. While Deplin claims to work through a “natural process in the brain to regulate all three monoamine neurotransmitters associated with mood by providing the increased dietary requirements for folate”, we all know this is not natural.
People who are thinking of using Deplin need to realize that it can dramatically alter you blood pressure levels. If you know that you are sensitive to this issue, then you should speak to your doctor first, or simply avoid using this supplement.
There are also other people using Deplin that complained of sleepless nights and strange dreams, as such you should not overlook the negative reactions that can occur with this product. We found these customer reviews via the Internet, so we suggest you also research further if you know you are at risk.
Deplin Price
Deplin’s price will vary based on concentration (7.5 mg, 8 mg, 15 mg or 75 mg). However, this is a very expensive form of treatment and many consumers may not be able to afford it.
This product should be available for purchase from various online retailers. Some retailers may offer additional discounts but the overall cost of the treatment will remain extremely high.
If you can’t afford Deplin, it is recommended to talk with your doctor. He may be able to offer you alternative treatments. Please take into consideration that this product is recommended for severe depression only. If you are diagnosed with mild to moderate depression, anxiety or panic attacks, you should focus on more affordable treatments.
Does Deplin Work?
Deplin has received mixed reviews on the Internet. Some consumers appears to be satisfied with the results, while others are reporting poor results, unwanted side effects and even an increased level of depression after the treatment.
This supplement is extremely expensive and the manufacturer does not offer a free trial sample for those interested in starting a treatment with Deplin. Thus, we recommend our readers to further research into this product before making a final decision. We also recommend patients to consult with their doctor before taking this supplement. He may be able to offer you cheaper and safer alternatives.
Deplin may be appealing to those who suffer from severe depression. However, we believe there may be better options out there.
Customer Reviews
I was very optimistic that it was taking the edge off, albeit ever so slightly. I have increased the dosage to 1200mg and feel no change other than what I noticed at the beginning
You can easily tell if you need this medical food. There is a genetic test that costs around $200 (I think) that will tell you if you have the genetic mutation that prevents your body from converting folate to l-methylfolate. If you do have this mutation to a fairly severe degree than supplementing with deplin will help greatly. I have the genetic mutation at the second worst degree. That is some people cannot convert folate to l-methylfolate at all. I can convert it but at a reduced amount thus taking deplin has helped me a lot with depression and anxiety. My results for the genetic test are: compound heterozygous for the mutations, C677T and A1298C in the MTHFR gene. I felt better after taking deplin before I had the test done. My doctor thought the test was too expensive to try and since I was feeling better he thought there was no need to take the test but he was wrong. Knowing I have the genetic mutation means I will have to take this supplement my whole life and it validates my belief that it is not a placebo effect.
Perhaps this product just doesn’t work for me personally. I was hoping for big things but once again my hopes have been dashed after following the directions.
This caused me to have every bad nightmares, when I could eventually go to sleep. This side effect was noticeable immediately. I have stopped using it, it did not work for me.
This is alot more serious than most realize I believe. I had a horrible reaction and I will never touch this stuff again and would Never recommend, actually I vote Nay for anyone. U will get just as good of results w a proper diet and some amino’s. And No sides! THIS IS SERIOUSLY DANGEROUS! and not worth the small benefit to see whether or not u will end up in er bc of spiked blood pressure. ! Rediculous.
ive been taking it with prsitiqu,franky havent seen any reasons to continue its expensive it dosent seem to help and ive had my share of bad from deplin i cant say for but its expensive and ive not seen any help from it………………………….
This is the first antidepressant that has worked for me. I have BP and have been through some long spells of depression; the most recent was a weepy deep depression. After about a week of Deplin 15mg, I was no longer weepy and feeling depressed, but was still somewhat flat. Now at the end of 2 weeks, I feel somewhat close to normal (which I have not felt in a long time). Yes my dreams are more vivid and realistic but my days of feeling better have outweighed any dream that has lingered past my morning coffee. I think Deplin in combination with Lithium and Trazodone is the right mix for me and my BP. Feeling in control of my emotions for the first time in a LONG time and it feels great!
Deplin isn’t a antidepressant. It is the natural, active form of folic acid(Vitamin B9). It’s called 5-methyltetrahydrofolic acid or Metafolin and Deplin is just a high dose of it. For this reason you don’t need a prescription. Many people have certain genetic polymorphisms that reduce the conversion from folic acid to its activ form, which is quite bad, because it is necessary for the production of neurotransmitters like serotonin. Thats the reason it works so well with antidepressants. The body produces more neurotransmitters like dopamine and serotonin and the antidepressants inhibit their reuptake. That is one reason antidepressants don’t work well for many people.
Adam wrote that he had he had big trouble with it. Maybe he has an additional Vitamin B12 deficiency(anemia), which was unmasked by Metafolin/Deplin. Maybe slow tritration and a B Complex and Vitamin B12 may help. You have to treat the Vit B12 deficiency otherwise permanent neurological damage may occour!
This seems interesting:
https://sedonaweb.com/attach/schools/ECHfaculty/attach/doc-2508.pdf
Folate is the natural form. Deplin is a man-made version, L-methyl folate, and is available by prescription only. It is not an antidepressant but seems to help with depression, depression related to bipolar disorder, and schizophrenia. This is the active form of folate by prescription, but I wouldn’t take mega-doses of anything over the counter–folate or not– without medical advice.
I am taking Celexa and still struggling a bit with depression. (genetic) My doctor suggested Deplin. I have been taking it for almost 4 weeks and IT HAS DEFINITELY MADE A DIFFERENCE. No side effects. I didn’t realize it was making a difference until I reflected upon the last couple weeks. So grateful. Now I need to find out how much it will cost. Single and limited income.
This is a wonderful supplement to any depression therapy. It is obvious that many folks on here are NOT scientific or medical, and I am both. I personally use it, and it helps with energy, as well as depression levels.
I should have known deplin wasn’t going to do what I needed…..by the second time I met with dr Steven Lamm, I knew he was a quack. The doc was all jittery and seemed to be on powerful stimulants. He had given a bag full of different supplements he told me were samples. When the nasty receptionist told me I owed hundreds of dollars for the supplements, I should have just walked out. Instead, I paid and went to the drugstore with my prescription for the deplin…..
I have been taking deplin for 3-4 months. I have nutty dreams, wake up many times every night to urinate or just with so many thoughts jumping around in my head and have a difficult time going back to sleep. This had never happened to me before.
Now, all I wanna do is to find out how to wean off deplin and live a natural life.
blood pressure stayed normal. moods nicely stabilized. seems to work well for me. tired of feeling like a trainwreck all the time.
I have found Deplin 7.5 to be extremely beneficial in my treatment of bipolar disorder. I was trying many different anti-depressants and having a terrible time and then was introduced to Deplin. I take it in combination with Celexa, Wellbutrin, and Lithium and have been stable for almost 8 months. The trick is to find a great psychiatrist.
Just started this medication. I am a wait and see wha happens perso. If it works great if not at least I tried it.
It worked FANTASTIC for the first 3 days, then slowly diminished. Now for the first time in my life, I cry over well, – things. NEVER have I done that prior to taking this. I’ve stopped taking this, and am going to see if this is indeed the culprit.
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I just started a few days ago and it is working!
I did have had very realistic dreams, but nothing frightening. In fact I had a good dream and went back to sleep to go back into it. I dream a lot anyway, so perhaps it’s not the deplin.
I also do amino acid therapy and use a light box or bright light visor which helps enormously. I have been in a deep depression and now that I am better- it feels like a miracle.
BTW, I take lithium and lamotragine for BP
I have no problem that this isn’t natural-that doesn’t really mean anything in terms of results-and certainly, if it’s going to help me save my life, abd the only side effect is intense dreams, I’ll keep taking it-especially during a dreary winter.
I used 4 kinds of anti-depressant in the past namely: citalopram, paxil, welbutrin and cymbalta. After 7 moths of citalopram, I developed an allergic reaction: itching and rashes on my arms and face. With welbutrin SR i experienced palpitation, insomia and depression. I’m experiencing bad side effects of menopausal like hotflashes and anxiety. I was desperate because I had to be out of work for six weeks. I’m under stress too that i feltpressure on my left chest. My stress test and EKG results came back normal. On my last visit to my doctor, she prescribed deplin that could be taken alone or in combination with an antidepressant. After 2 weeks, i feel better and the pressure is gone. Although it is expensive I have no other choice but to take it but it’s worth the money.
I was diagnosed with pernicious anemia 15 years ago. I was no longer able to feel differences in temperature (hot or cold), texture ( sand paper from silk), and when I walked, I could not feel my feet touching the floor. My proprioception was completely messed up, and at night, if needing to get up for any reason, I could not tell if my hands were touching the wall or not, and would walk directly into a wall unless the light was on. I have been taking vitamin B12 by injection bi-weekly all this time, and there had been no difference. When my psychiatrist prescribed Deplin, a vitamin form that crosses the blood brain barrier, within 2 weeks, I could feel temperature, textures, and am not as clumsy as before. It is a miracle drug.
I have been taking deplin for about two weeks and I have noticed a huge difference in my mood and less anxious than I have been in a while. I am trying to decrease my medication that I am now on which is cymbalta bucebar and trazadone. I didnt want another pill to help me through my panic attacks and depression so I looked for a more natural outlook and I hope it helps you out as it did to me.